Transcriptional silencing of -globin by BCL11A involves long-range interactions and cooperation with SOX6
نویسندگان
چکیده
Article is available under a Creative Commons license; see publisher's site for details. The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters.
منابع مشابه
Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.
The developmental switch from human fetal (gamma) to adult (beta) hemoglobin represents a clinically important example of developmental gene regulation. The transcription factor BCL11A is a central mediator of gamma-globin silencing and hemoglobin switching. Here we determine chromatin occupancy of BCL11A at the human beta-globin locus and other genomic regions in vivo by high-resolution chroma...
متن کاملCorepressor-dependent silencing of fetal hemoglobin expression by BCL11A.
Reactivation of fetal hemoglobin (HbF) in adults ameliorates the severity of the common β-globin disorders. The transcription factor BCL11A is a critical modulator of hemoglobin switching and HbF silencing, yet the molecular mechanism through which BCL11A coordinates the developmental switch is incompletely understood. Particularly, the identities of BCL11A cooperating protein complexes and the...
متن کاملDistinct Ldb1/NLI complexes orchestrate γ-globin repression and reactivation through ETO2 in human adult erythroid cells.
The Ldb1/GATA-1/TAL1/LMO2 complex mediates long-range interaction between the β-globin locus control region (LCR) and gene in adult mouse erythroid cells, but whether this complex mediates chromatin interactions at other developmental stages or in human cells is unknown. We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the β-globin locus in human erythroid cell...
متن کاملRED CELLS, IRON, AND ERYTHROPOIESIS Distinct Ldb1/NLI complexes orchestrate -globin repression and reactivation through ETO2 in human adult erythroid cells
The Ldb1/GATA-1/TAL1/LMO2 complex mediates long-range interaction between the -globin locus control region (LCR) and gene in adult mouse erythroid cells, but whether this complex mediates chromatin interactions at other developmental stages or in human cells is unknown. We investigated NLI (Ldb1 homolog) complex occupancy and chromatin conformation of the -globin locus in human erythroid cells....
متن کاملTranscription. Gene expression--where to start?
then the causative SNP either has a non–tissue-specific effect on transcription, or it acts at the posttranscriptional level, an issue that remains to be resolved. Although the results are consistent with the long isoforms of BCL11A functioning to suppress HbF production in a dose-dependent manner, they do not distinguish between a direct effect on γ-globin gene expression and an indirect effec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010